Question

What activates TCA cycle?

Answer 1

Kreb's cycle:

1. The Krebs cycle, also known as the citric acid cycle, is a sequence of enzyme-catalyzed processes that involve the oxidation of acetyl-CoA to produce carbon dioxide and the reduction of coenzymes to produce ATP for the electron transport chain.
2. It takes place in the mitochondrial matrix
3. Pyruvate dehydrogenase, the initial enzyme in the pyruvate dehydrogenase complex process that produces acetyl-CoA, is activated by calcium ions to control the citric acid cycle.
4. Isocitrate dehydrogenase and $\mathrm{\alpha }-$-ketoglutarate dehydrogenase, which catalyzes the phases of the cycle, is also activated by calcium ions.
5. The rate of individual reactions within the cycle is increased by the activation of these enzymes by calcium ions, increasing cycle output overall.
6. ADP's capacity to generate ATP is used in reactions that are accelerated when its concentration rises.
7. Because there is no phosphate acceptor or inorganic phosphate present when ADP is present in less concentration, the amount of ATP produced by oxidative phosphorylation decreases.
8. Succinyl-CoA synthetase, an inorganic phosphate group linked with a GDP molecule, is responsible for the conversion of succinyl-CoA into succinate. Guanosine triphosphate, or GTP, is produced through the conversion of GDP, or guanosine diphosphate.
9. The cycle is triggered by ADP, inorganic phosphate, and calcium while it is inhibited by NADH and ATP.
10. It is the only energy unit produced in the Krebs cycle