Question

What happens when a frameshift mutation occurs?

Answer 1

Frameshift mutation:

1. These are the mutations that occur due to the addition or deletion of one or two nucleotides in the coding region of a gene causing a change in the reading frame of codons in mRNA that leads to the premature translation of proteins or chain termination.
2. The reading frame of the protein-coding gene starts with an AUG start codon and ends with a UGA stop codon is known as the reading frame.
3. If a nucleotide is added or deleted from this reading frame i.e frameshift mutation occurs, then the reading frame will be shifted or gets changed by one nucleotide pair and thus the mRNA formed in this sequence will have an altered codon, which on translation will result in termination of protein synthesis.
4. Cystic fibrosis is a disease that occurs due to frameshift mutation.