Question

What happens when the bond formed between an enzyme and an inhibitor is
a strong covalent bond?

Answer 1

When the bond formed between an enzyme and an inhibitor is a strong covalent bond, irreversible inhibition will occur. An irreversible enzyme inhibitor forms a strong covalent bond at the enzyme active site with amino acid side chain group. As the bond formed is a strong bond additional substrate addition does not reverse the inhibition process and the enzyme is permanently deactivated. Thus the body degrade the enzyme inhibitor complex and synthesis of new enzyme.
Eg., Organophosphate insecticide