Question

What is false about sickle cell anaemia ______________.

• A. Genotype $H{b}^{A}H{b}^S$
• B. Genotype $H{b}^{A}H{b}^A$
• C. Sickle shaped RBC
• D. Substitution of glutamic acid by valine.

Answer 1

The correct option is B Genotype $H{b}^{A}H{b}^A$

Sickle cell anaemia is an autosomal disorder. It is the most common genetical disorder appear in Africans. It is due to the homozygous condition of the gene Hb^S Hb^S. The disease is due to the substitution of sixth codon in gene coding for the b-chain of Haemoglobin. Due to this, sixth amino acid in b-chain of Haemoglobin Glutamic acid is replaced by valine. The main symptom of this disorder is decrease of oxygen uptake.

So, the correct option is ‘Genotype Hb^A Hb^A.