Question

What is the benefit of using a retrovirus as a vector in gene therapy?

• A. It is not able to enter cells
• B. It eliminates a lot of unnecessary steps
• C. It incorporates the foreign gene into the host chromosome
• D. Both (b) and (C)

Answer 1

The correct option is D Both (b) and (C)

Retroviruses are a class of enveloped viruses that contain a single-stranded RNA genome. They are able to efficiently integrate permanently into the human genome after entering cells, where they provide the basis for permanent expression of foreign DNA. They offer several benefits like the integration of the gene of interest into chromosomes, stable expression, reducing a lot of unnecessary steps required when we go by gene therapy by other methods and the unique life cycle of the virus causing no immunogenicity.

So, the correct option is 'Both (b) and (C)'.