Receptors are present in all parts of our body such as in skin, eye, nose, tongue etc. They detect the signals and then send them to the brain in the form of electrical signals.
Receptors can become dysfunctional temporarily or sometimes permanently depend upon the level of exposure to a certain stimulus. For example, the laser beam entering directly into the eyes can burn the retinal cells and can make a person temporarily or permanently blind, depending upon the length of the period for which the exposure is sustained. Similar is the case of burns, a mild burn can desensitise the skin for some time but a significant burn can cause a permanent loss of sensation in the burnt area.
The associated problem includes loss of stimulus from that particular receptor, which hampers coordination within the body.