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Question

What makes RNA mutate faster than DNA?

A
The presence of uracil in place of thymine
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B
Single-stranded structure
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C
The 2’-OH group
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D
None of these
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Solution

The correct options are
A The presence of uracil in place of thymine
B Single-stranded structure
C The 2’-OH group
In spite of the similarities exhibited by DNA and RNA, a few differences do exist, making DNA a relatively better genetic material. The most important of these is the 2’-OH group at every nucleotide of RNA. This is a reactive group, making RNA less stable than DNA. In addition, the structural difference between uracil and thymine (Thymine has a methyl group which is absent in uracil) too, confers additional stability to DNA. The predominantly single-stranded nature of RNA makes it prone to more damage than double-stranded DNA.

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