Question

What will happen if the secretion of pariental cells of gastric glands is blocked with an inhibitor?

• A. Gastric juice will be deficient in chymosin
• B. Gastric juice will be deficient in pepsinogen
• C. In the absence of HCl secretion, inactive pepsinogen is not converted into the active enzyme pepsin
• D. Enterokinase will not be released from the duodenal mucosa and so trypsinogen is not converted to trypsin

Answer 1

Answer: (C)

In the absence of HCl secretion, inactive pepsinogen is not converted into the active enzyme pepsin

The fundic glands in the fundic part of stomach contain peptic or chief cells, which produce pepsinogen and parietal or oxyntic cells, which produce hydrochloric acid. The hydrochloric acid makes gastric juice acidic (pH 2 to 3.7) and activates pepsinogen into pepsin. Pepsin is the principal protein-splitting enzyme of the stomach.

So, the correct answer is option C.