Question

What will happen if the secretion of parietal cells of gastric glands is blocked with an inhibitor?

• A. In the absence of HCl secretion inactive pepsinogen is not converted into the active enzyme pepsin.
• B. Enterokinase will not be released from the duodenal mucosa and so trypsinogen is not converted to trypsin.
• C. Gastric juice will be deficient in chymosin.
• D. Gastric juice will be deficient in pepsinogen.

Answer 1

The correct option is A In the absence of HCl secretion inactive pepsinogen is not converted into the active enzyme pepsin.

Numerous microscopic, tubular glands are formed by the epithelium of the stomach. Chief cells or peptic cells (zymogen cells) secrete gastric digestive enzymes like proenzymes or zymogens, pepsinogen and prorennin. Pepsinogen, the inactive precursor form of pepsin is activated by hydrochloric acid. The hydrochloric acid is secreted by oxyntic or parietal cells of stomach. So, in absence of HCl, the pepsinogen will not be converted to pepsin.