Question

What will happen if the secretion of parietal cells of gastric glands is blocked with an inhibitor?

• A. In the absence of HCl secretion, inactive pepsinogen is not converted into the active enzyme pepsin.
• B. Enterokinase will not be released from the duodenal mucosa and so trypsinogen is not converted to trypsin.
• C. Gastric juice will be deficient in chymosin.
• D. Gastric juice will be deficient in pepsinogen.

Answer 1

Answer: (A)

In the absence of HCl secretion, inactive pepsinogen is not converted into the active enzyme pepsin.

Parietal cells are the stomach epithelial cells that secrete gastric acid (HCl) and intrinsic factor. These cells are located in the fundus. Gastric HCl activates pepsinogen and converted into the pepsin that breaks the peptide bonds by a process known as proteolysis. So in the absence of HCl secretion, inactive pepsinogen is not converted into the active enzyme pepsin.

So, the correct answer is 'In the absence of HCl secretion, inactive pepsinogen is not converted into the active enzyme pepsin'.