Question

When the mutation at one locus is neutralized by the mutation at another locus of same or different chromosome, it is termed as

• A. Gibberish mutation
• B. Backward mutation
• C. Crossing over
• D. Neutral mutation
• E. Suppressor mutation

Answer 1

The correct option is E Suppressor mutation

The gene mutations that alter the base sequence of the whole genetic frame from the point of the mutation are called as frame shift mutations. Here, the reading frame of the base sequence is shifted forward (due to insertion of one or more nucleotide base) or in the backward direction (due to deletion of one or more nucleotide base). The frameshift mutations are sometimes called as gibberish mutations because they make the amino acid sequence meaningless and protein nonfunctional. The mutation in the mutant form of a gene that restores its wild-type form by a second mutation at the same locus, where the first mutation occurred, is the backward mutation. Crossing over is the process of exchange of genetic material between non-sister chromatids of homologous chromosomes to produce new genetics combinations or variations. Neutral mutations are the one that either cause no change in the gene expression or does not affect the protein functioning; the presence of wobble base, the large amount of junk DNA is the key to neutral mutation. A suppressor mutation is a second mutation in the same gene but at a different locus to compensate for the forward mutation in the gene product. Thus, there are two mutations but the gene codes for a same protein with structure and function just like the original, wild type protein. The correct answer is E.