Which 5-carbon organic acid of TCA cycle is key compound in a N $_{2}$ metabolism?

Citric acid

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Fumaric acid

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Isocitrate

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α

-ketoglutaric acid

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Solution

The correct option is D $α$ -ketoglutaric acid
Krebs cycle leads to the production of α-Ketoglutarate as key intermediate after isocitrate and before succinyl-CoA.α-Ketoglutarate is one of the most important nitrogen transporters in metabolic pathways. The amino groups of amino acids are attached to it (by transamination) to transport it to the liver for ornithine cycle. So, the correct answer is option D.

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α

α

C O_{2}

\begin{matrix} I . C i t r i c a c i d & \to & α - k e t o g l u t a r i c a c i d I I . S u c c i n i c a c i d & \to & M a l i c a c i d I I I . M a l i c a c i d & \to & O x a l o a c e t i c a c i d I V . α - k e t o g l u t a r i c a c i d & \to & S u c c i n y l C o - A \end{matrix}

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