Which among the following intermediates of TCA cycle can enter amino acid biosynthesis?

Alpha-ketoglutaric acid

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Malic acid

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Citric acid

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Isocitric acid

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Solution

The correct option is A Alpha-ketoglutaric acid
TCA cycle is an amphibolic pathway in which some substrates like the alpha-ketoglutarate, oxaloacetate, citrate, acetyl CoA etc. can be used both in catabolic and anabolic pathways. Alpha-ketoglutarate (alpha-ketoglutaric acid) is used in the synthesis of various amino acids like the glutamate.

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