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Question
Which among the following is a competitive inhibitor of succinic dehydrogenase?
Which among the following is a competitive inhibitor of succinic dehydrogenase?
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Solution
The correct option is C Malonate
In eukaryotes, succinate dehydrogenase is tightly bound to the inner mitochondrial membrane and in prokaryotes, to the plasma membrane. The enzyme contains three different iron-sulfur clusters and one molecule of covalently bound FAD. Electrons pass from succinate through the FAD and iron-sulfur centers before entering the chain of electron carriers in the mitochondrial inner membrane (or the plasma membrane in bacteria). Electron flow from succinate through these carriers to the final electron acceptor, O2, is coupled to the synthesis of about 1.5 ATP molecules per pair of electrons (respiration-linked phosphorylation). Malonate, an analog of succinate not normally present in cells, is a strong competitive inhibitor of succinate dehydrogenase and its addition to mitochondria blocks the activity of the citric acid cycle.
In eukaryotes, succinate dehydrogenase is tightly bound to the inner mitochondrial membrane and in prokaryotes, to the plasma membrane. The enzyme contains three different iron-sulfur clusters and one molecule of covalently bound FAD. Electrons pass from succinate through the FAD and iron-sulfur centers before entering the chain of electron carriers in the mitochondrial inner membrane (or the plasma membrane in bacteria). Electron flow from succinate through these carriers to the final electron acceptor, O2, is coupled to the synthesis of about 1.5 ATP molecules per pair of electrons (respiration-linked phosphorylation). Malonate, an analog of succinate not normally present in cells, is a strong competitive inhibitor of succinate dehydrogenase and its addition to mitochondria blocks the activity of the citric acid cycle.
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