Question

Which among the following is/are correct regarding alpha and beta thalassemia?
(A) Number of gene mutations decide the severity of the condition
(B) Haemoglobin fails to produce enough alpha protein of myoglobin in alpha-thalassemia
(C) Haemoglobin fails to produce enough alpha protein of haemoglobin in alpha-thalassemia
(D) Haemoglobin fails to produce enough beta protein of haemoglobin in beta-thalassemia
(E) Thalassemia (alpha and beta) is a qualitative disorder

• A. A, B, E are correct and C, E are incorrect
  
• B. A, C, D are correct and B, E are incorrect
• C. B, C, D are correct and A, E are incorrect
• D. A, C, E are correct and B, D are incorrect

Answer 1

The correct option is B A, C, D are correct and B, E are incorrect

Thalassemia is a quantitative disorder as the quantity (amount) of synthesis of the haemoglobin chain is affected. Number of gene mutations decides the severity of the condition. In alpha-thalassemia, haemoglobin fails to produce enough alpha protein of haemoglobin while in beta -thalassemia, production of the beta globin chain is affected.