Question

Which antibiotic inhibits peptide bond formation

• A.
  Neomycin
• B.
  Chloramphenicol
• C.
  Tetracycline
• D.
  Streptomycin

Answer 1

The correct option is B

Chloramphenicol
Streptomycin
Streptomycin acts by inhibiting the initiation of translation and also causes misreading of the codon.

Tetracycline
Tetracycline acts by inhibiting the binding of aminoacyl tRNA to ribosomes.

Chloramphenicol
Chloramphenicol inhibits the activity of the peptidyl transferase enzyme which catalyses the formation of peptide bonds between the amino acids.

Neomycin
Neomycin irreversibly binds to the 30S subunit of the ribosome, thus inhibiting the interaction between tRNA and mRNA. This will lead to inhibition of translation.