Which is the most reactive of the following?

Ethyl acetate

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Acetic anhydride

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Acetamide

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Acetyl chloride

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Solution

The correct option is D Acetyl chloride
The order of reactivity of acid derivatives towards different
reactions decreases in the order

$R C O C l > (R C O)_{2} O > R C O O R^{'} > R C O N H_{2}$

In other words, the reactivity decreases as the basicity of the
leaving group increases i.e.,

$C l^{-} < R C O O^{-} < R O^{-} < N H_{2}^{-}$

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