Question

Which of the following causes denaturation of proteins?

• A. Change in $pH$
• B. Exposure to heat
• C. Exposure to acid or bases
• D. None of the above

Answer 1

Answer: (A), (B), (C)

Exposure to acid or bases

When proteins are subjected to external stress like addition of acids and bases, exposure to heat, or change in $pH$, the hydrogen bonds in the proteins are deteriorated and helix gets uncoiled, thus losing its biological activity.