Which of the following is essential for the conversion of pyruvic acid to acetyl CoA?

TPP

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NAD

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ATP

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LAA

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Solution

The correct option is A
TPP

Pyruvic acid enters the mitochondrial matrix, undergoes oxidative decarboxylation and forms acetyl CoA by a series of reactions catalysed by the multienzyme complex. The reaction requires participation of the enzyme pyruvate dehydrogenase and several coenzymes including NAD⁺, coenzyme A, thiamine pyrophosphate (TPP) and lipoic acid.

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