Which of the following mammalian cells is not capable of metabolizing glucose to carbon dioxide aerobically?
The correct option is A Red blood cells
In humans, mature red blood cells are flexible and oval biconcave disks. They lack a cell nucleus and most organelles, including mitochondria, in order to accommodate the oxygen carrying protein- hemoglobin and also to enable them to bend and squeeze through small blood capillaries while delivering oxygen to remote regions of the body. Since the mitochondria are the cellular site for oxidative metabolism, where glucose is broken down to carbon dioxide and water to release energy, and because red blood cells lack these organelles they cannot breakdown glucose completely aerobically. Therefore red blood cells rely on anaerobic glycolysis which occurs in the cytoplasm for their energy needs.