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Question

Which of the following protein is responsible for spontaneous blood clotting?

A
Factor XII
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B
Factor XI
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C
Factor IX
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D
Factor VIII
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Solution

The correct option is C Factor VIII
Factor VIII is an important blood clotting protein, which is also known as anti-haemophilic factor (AHF), encoded by the F8 gene.
Factor VIII circulates in the bloodstream in an inactive form, bound to another molecule, called Von Willebrand factor, until an injury that damages the blood vessels occurs. When injury occurs, the factor VIII is activated and separates from Von Willebrand factor. The active protein interacts with another coagulation factor, called factor IX. This interaction leads to a chain of additional reactions, that form a blood clot.

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