Which of the following reactions is appropriate to convert acetamide to methanamine?
A
Stephen's reaction
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B
Gabriel synthesis
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C
Carbylamine reaction
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D
Hofmann bromamide degradation
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Solution
The correct option is D Hofmann bromamide degradation There could be several names - all of them valid.
Hofmann rearrangement, or Hofmann degradation reaction or Hofmann bromamide reaction. As you can see,
the product as one carbon atom fewer than the substrate.