Question

Which of the following statements regarding enzyme inhibition is correct?

• A. Competivitive inhibition is seen when a substrate competes with an enzyme for binding to an inhibitor protein
• B. Non -competitive inhibitors often bind to the enzyme irreversibly
• C. Competitive inhibition is seen when the substrate and the inhibitor compete for the active site on the enzyme
• D. Non-competitive inhibition of an enzyme can be overcome by adding large amount of substrate

Answer 1

The correct option is C Competitive inhibition is seen when the substrate and the inhibitor compete for the active site on the enzyme

Competitive Inhibition occurs when the binding of the inhibitor to the active site on the enzyme prevents the binding of the substrate and vice versa.
The binding of competitive inhibitors to enzymes are reversible.
Noncompetitive inhibition occurs when the inhibitor binds to the enzyme at a site away from the active site such that even on binding of the substrate, the enzyme functions less effectively. This type of inhibition is reversible and cannot be overcome by adding a large amount of substrate.