Question

Which of the following statements regarding HIV and its entry into target cells are correct?
A. The initial binding event occurs between viral Gp120 and CD4 receptors.
B. It belongs to the genus Flavivirus.
C. Virus entry proceeds through fusion of the viral envelope with the target cell membrane.
D. Only reverse transcriptase gains entry inside the target cell.

• A. A and B
• B. A and C
• C. C and D
• D. B and C

Answer 1

The correct option is B A and C

1. GP120 of the virus recognizes CD4 receptors over the host cells and binds to it.
2. HIV belongs to the family of retroviruses.
3. Viral protein GP41 binds to the co-receptor protein CCR5/CXCR4 and this binding mediates fusion between the lipid bilayer of the virus and the cell membrane of the host cell.
4. Enzymes reverse transcriptase and integrase enter the target host cell, the ssRNA molecules and the P24 nucleocapsid.