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Question

Which of the following substances yield less than 4Kcal/mol, when its phosphate bond is hydrolysed?

A
Creatine phosphate
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B
ADP
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C
Glucose-6-phosphate
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D
ATP
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Solution

The correct option is A Glucose-6-phosphate

The reaction in which the hydrolysis of the phosphate bond in ATP takes place gives rise to free energy range of 7.3 Kcal/mol, when ADP is hydrolysed, the reaction also gives free energy in the range of 7.3 Kcal/mol.
Creatine phosphate is also a high energy phosphate compound. The reason for high free energy is due to difference of free energy contents in reactants and products. The process of glycolysis involves the conversion of glucose to glucose-6-phosphate by phosphorylation process. Hydrolysis of glucose 6-phosphate gives an yield of -3.3 Kcal/mol, which is less than 4 Kcal/ mol. Thus, the correct answer is option C.

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