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Question
Which of these is used as vector for gene therapy is SCID and gene cloning in higher organisms?
Which of these is used as vector for gene therapy is SCID and gene cloning in higher organisms?
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Solution
The correct option is B Retrovirus
Retrovirus
Retrovirus is a class of viruses that have two single stranded RNAs as their genetic material and have reverse transcriptase enzymes. On infecting cells with DNA, the viral genetic material gets reverse transcribed. Incorporation of the viral DNA into the host genetic material helps hijack the cellular machinery of the host.
Retroviral vector
Retroviral vector is derived from the retrovirus genome carrying a provirus sequence that can accommodate a gene of interest. This mediates the incorporation of the gene of interest in the host genome.
Gene therapy
Gene therapy is the collection of methods in which a defective gene present in the embryo or child is corrected by replacing it with a normal gene to compensate for the malfunctioning of the defective gene.
SCID
Severe Combined ImmunoDeficiency Syndrome (SCID) is a disorder caused by a mutation in gene encoding for the enzyme adenosine deaminase (ADA).
Lack of ADA gene results in depletion of T-lymphocytes and also affects the development and activation of B cells.
Vector used for SCID treatment
Gene therapy for SCID involves a retroviral vector. Patients' lymphocytes are genetically engineered with a functional copy of ADA cDNA using retroviral vector and infused back into their blood.
Enterovirus
Enterovirus are a group of viruses that infects humans and have a single stranded RNA as a genetic material.
Arbovirus
Arbovirus are a group of viruses that communicate through arthropod vectors.
Rotavirus
Rotavirus are a group of viruses that have double stranded RNA as their genetic material.
Final answer:
(a) Retrovirus
Retrovirus
Retrovirus is a class of viruses that have two single stranded RNAs as their genetic material and have reverse transcriptase enzymes. On infecting cells with DNA, the viral genetic material gets reverse transcribed. Incorporation of the viral DNA into the host genetic material helps hijack the cellular machinery of the host.
Retroviral vector
Retroviral vector is derived from the retrovirus genome carrying a provirus sequence that can accommodate a gene of interest. This mediates the incorporation of the gene of interest in the host genome.
Gene therapy
Gene therapy is the collection of methods in which a defective gene present in the embryo or child is corrected by replacing it with a normal gene to compensate for the malfunctioning of the defective gene.
SCID
Severe Combined ImmunoDeficiency Syndrome (SCID) is a disorder caused by a mutation in gene encoding for the enzyme adenosine deaminase (ADA).
Lack of ADA gene results in depletion of T-lymphocytes and also affects the development and activation of B cells.
Vector used for SCID treatment
Gene therapy for SCID involves a retroviral vector. Patients' lymphocytes are genetically engineered with a functional copy of ADA cDNA using retroviral vector and infused back into their blood.
Enterovirus
Enterovirus are a group of viruses that infects humans and have a single stranded RNA as a genetic material.
Arbovirus
Arbovirus are a group of viruses that communicate through arthropod vectors.
Rotavirus
Rotavirus are a group of viruses that have double stranded RNA as their genetic material.
Final answer:
(a) Retrovirus
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