Which one of the following does not involve isomerisation in glycolysis pathway?

Conversion of glucose-6-phosphate to fructose-6-phosphate

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Conversion of glycerol aldehyde-3-phosphate to dihydroxyacetone phosphate

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Conversion of 3-phosphoglyceric acid to 2-phosphoglyceric acid

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Conversion of 2-phosphoglyceric acid to phospho enol pyruvic acid

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Solution

The correct option is D Conversion of 2-phosphoglyceric acid to phospho enol pyruvic acid
In the ninth step of glycolysis, 2-phosphoglyceric acid (2-PGA) is converted into phosphoenolpyruvic acid (PEP) by removal of one water molecule. These two molecules, 2-PGA and PEP are not isomers. All the other molecules mentioned here are isomers and their reactions are reversible, therefore they are interconvertible.

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