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Question
Who proposed cAMP mediated 'Cascade model' of enzyme regulation?
Who proposed cAMP mediated 'Cascade model' of enzyme regulation?
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Solution
The correct option is C Sutherland
cAMP is produced from ATP by the enzyme adenylyl cyclase. This enzyme is important for regulation of enzyme activities. cAMP acts as second messenger in many hormone responses and is a regulator for many enzyme. A cascade mechanism ensures magnification of the initial signal, also a single switch off reaction in the cascade will ensure easy, efficient and effective cut off of the entire pathway. Nobel Prize was awarded to Earl Sutherland, in 1971, for discovering the key role of adenylyl cyclase III in human liver, where adrenaline indirectly stimulates adenylyl cyclase to mobilize stored energy in the "fight or flight" response.
cAMP is produced from ATP by the enzyme adenylyl cyclase. This enzyme is important for regulation of enzyme activities. cAMP acts as second messenger in many hormone responses and is a regulator for many enzyme. A cascade mechanism ensures magnification of the initial signal, also a single switch off reaction in the cascade will ensure easy, efficient and effective cut off of the entire pathway. Nobel Prize was awarded to Earl Sutherland, in 1971, for discovering the key role of adenylyl cyclase III in human liver, where adrenaline indirectly stimulates adenylyl cyclase to mobilize stored energy in the "fight or flight" response.
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