Question

Wobble hypothesis deals with

• A. Phenomena of multiple codons coding for the code for a single amino acid
• B. Phenomena of multiple codons coding for the code for a different amino acid
• C. Phenomena of anticodon coding for the code for a different amino acid
• D. Phenomena of anticodon coding for the code for more than one amino acid

Answer 1

The correct option is A Phenomena of multiple codons coding for the code for a single amino acid

• The wobble hypothesis deals with the phenomenon of degeneracy that is seen in the genetic code through tRNA recognition of more than one codon.
• Each tRNA contains a triplet anti-codon that is complementary to a codon in mRNA. The first two pairs should be complementary for binding to occur, but the third pair need not always be complementary. This is the wobble in the genetic code.
• Each mRNA is made up of four different nucleotide bases (A, G, U, and C) and codons are made up of three of these bases,
• Thus, 64 possible codon configurations exist. So it would be expected that there would be 64 tRNA and 64 associated amino acids.
• However, only 21 amino acids exist. This means that some tRNA must bind multiple codons and provide the same amino acid for different codon configurations.

Thus, the correct answer is option A.