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Wobble hypothesis for genetic code was given by
Wobble hypothesis for genetic code was given by
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Solution
The correct option is B Crick
Wobble hypothesis is based on the observation that, the base in first position of anti-codon on tRNA is usually an abnormal base, like inosine, pseudouridine, tyrosine etc. These abnormal bases pair with more than one type of nitrogenous base in the third position of the codon on mRNA; Inosine (I) can pair with A, C or U. This base is called Wobble base which is present at position 1 of the anti-codon and position 3 of the codon. According to Wobble hypothesis, the third position of the codon on mRNA and the first position of the anticodon on tRNA are bound less tightly than the other two pair and provide unusual base combinations. Due to genetic code degeneracy, many amino acids share the third base and differ in first two bases only thereby making the third base less important. It was given by Crick.
Wobble hypothesis is based on the observation that, the base in first position of anti-codon on tRNA is usually an abnormal base, like inosine, pseudouridine, tyrosine etc. These abnormal bases pair with more than one type of nitrogenous base in the third position of the codon on mRNA; Inosine (I) can pair with A, C or U. This base is called Wobble base which is present at position 1 of the anti-codon and position 3 of the codon. According to Wobble hypothesis, the third position of the codon on mRNA and the first position of the anticodon on tRNA are bound less tightly than the other two pair and provide unusual base combinations. Due to genetic code degeneracy, many amino acids share the third base and differ in first two bases only thereby making the third base less important. It was given by Crick.
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