Nephrons are structural and functional unit of the kidney. Each nephron in the mammalian kidney is a long tubule. At one end this tube is closed, expanded, and folded into a double-walled cuplike structure. This structure, called the renal corpuscular capsule, or Bowman’s capsule, encloses a cluster of microscopic blood vessels—capillaries—called the glomerulus. The capsule and glomerulus together constitute the renal corpuscle. Blood flows into and away from the glomerulus through tiny arteries called arterioles, which reach and leave the glomerulus through the open end of the capsule. In the renal corpuscle, fluid filters out of the blood in the glomerulus through the inner wall of the capsule and into the nephron tubule. As this filtrate passes through the tubule, its composition is altered by the secretion of certain substances into it and by the selective reabsorption of water and other constituents from it. The final product is urine, which is conveyed through the collecting tubules into the renal pelvis.