Question

Sickle cell anemia is a case of

• A. Transition mutation
• B. Transversion mutation
• C. Frameshift mutation
• D. Silent mutation

Answer 1

The correct option is B

Transversion mutation

The correct option is B.

The explanation for the correct option:

1. When one purine is replaced by one pyrimidine base or vice versa, the point mutation happening is referred to as Transversion mutation.
2. In sickle cell anemia, one Adenine is changed by one Thymine base.
3. This leads to the formation of Valine instead of Glutamine.
4. And this reduces the oxygen-carrying potential of Hemoglobin.
5. Hence, sickle cell anemia is a Transversion mutation.

The explanation for the incorrect options:

Option A:

1. When one pyrimidine base is replaced by another pyrimidine base, the point mutation is referred to as Transition mutation.
2. In this case, Thymine is replaced by Thymine only.

Option C:

1. When a sequence is deleted or inserted in the Normal sequence, and this changes genetic code readings, the phenomenon is referred to as Frameshift mutation.
2. This frameshift mutation leads to the formation of false amino acids or proteins.

Option D:

1. When a mutation does not show any phenotypic effect, then the phenomenon is referred to as Silent Mutation.
2. It is also a kind of point mutation but even after mutation, normal proteins and amino acids are synthesized.

Final answer:

Sickle cell anemia is an example of Transversion mutation.