Down Syndrome

Q.

Down’s Syndrome is a classic case of polyploidy.

1. True

2. False

Q.

Which one of the following conditions in humans is correctly matched with its chromosomal abnormality/linkage?

1. Down’s syndrome ­- 44 autosomes + XO

2. Erythroblastosis foetalis -­ X-­linked

3. Colour blindness­ – Y-­linked

4. Klinefelter’s syndrome­ – 44 autosomes + XXY

Q. Which of the following statements is incorrect with respect to aneuploidy?

1. It is caused due to failure of chromatid segregation
2. It is caused due to failure of cytokinesis
3. It results in lack or excess copies of a particular chromosome(s)
4. Down’s syndrome is an example of aneuploidy

Q.

What is the meaning of aneuploidy?

Q.

What is positive fluid balance or hypervolemia?

Q. A woman with 47 chromosome due to three copies of chromosome 21 is characterized by

1. superfemales
2. triploidy
3. Turner's syndrome
4. Down's syndrome

Q. Turner syndrome is due to

1. Loss of any chromosome
2. Loss of X chromosome - 44 + XO
3. It is due to trisomy in 21 st pair
4. None

Q.

Down’s Syndrome is a classic case of polyploidy.

1. True

2. False

Q.

Which of the following is not related to sex chromosome X or Y?

1. Turners syndrome

2. Klinefelters syndrome

3. Downs syndrome

4. Haemophilia and color blindness

Q.

Can Down syndrome go undetected?

Q.

In the above given pedigree, assume that no outsider marrying in, carry a disease. Write the genotypes of II and III.

1. 
   All $X^{d}Y$
2. $X^{D}Yand{X}^D{X}^d$
3. 
   $X^{d}X{X}^{d}Yand{X}^{d}Y$
4. 
   $X^d{X}^{d}and{X}^{d}Y$

Q.

What are the signs and symptoms of chromosomal abnormalities?

Q.

What are aneuploidy and tetraploidy in cancer cells?

Q. While studying karyotypes, a student had drawn the karyotypes of two cells, one from an individual with Klinefelter’s syndrome (A) and the other from an individual with Down’s syndrome (B).
The difference between the number of chromosomes between A and B is _______.

1. 2
2. 1
3. 3
4. 0

Q. A disease caused by an autosomal primary non-disjunction is:

1. Down's Syndrome
2. Klinefelter's Syndrome
3. Turner's Syndrome
4. Sickle cell anemia

Q.

What happens if you have aneuploidy?

Q.

How do you get zellweger syndrome?

Q. A women with 47 chromosomes due to three copies of chromosome 21 is characterized by :

1. Turner syndrome
2. Down syndrome
3. Super femaleness
4. Triploidy

Q.

What can cause several chromosomal disorders?

Q. The "Cri-du-Chat" syndrome is caused by a change in chromosome structure due to

1. Deletion
2. Duplication
3. Inversion
4. Translocation

Q. If a person stays on Mount Everest for some days

1. His body will step up production of RBC
2. His body will step down production of RBC
3. Number of RBC will not change
4. His RBC will turn into very large cells

Q.

Can you be half Down syndrome?

Q. Which one of the following conditions of the gastrula would lead to the birth of a normal human female child?

1. One X and one Y chromosome
2. Two X chromosomes and both are fully functional
3. Two X chromosomes but only one is functional
4. Only one X chromosome which is functional

Q.

Down Syndrome is caused by trisomy of chromosome 21. True or false?

1. True

2. False

Q. Down syndrome is caused by an extra copy of chromosome number 21. What percentage of offspring produced by an affected mother and a normal father would be affected by this disorder?

1. $100\%$
2. $75\%$
3. $50\%$
4. $25\%$

Q.

Are babies with Down syndrome born early?

Q.

A patient suffering from haemophilia is most likely to die due to the lack of oxygen in the body.

1. True

2. False

Q. Down syndrome is caused by an extra copy of chromosome number 21. What percentage of offspring produced by an affected mother and a normal father would be affected by this disorder?

1. $100\%$
2. $75\%$
3. $50\%$
4. $25\%$

Q.

In the above given pedigree, assume that no outsider marrying in, carry a disease. Write the genotypes of II and III.

1. 
   All $X^{d}Y$
2. $X^{D}Yand{X}^D{X}^d$
3. 
   $X^{d}X{X}^{d}Yand{X}^{d}Y$
4. 
   $X^d{X}^{d}and{X}^{d}Y$

Q.

how many number of chromosome a person with Turners syndrome has?