Wobble Hypothesis

Q.

QUESTION: Length of double stranded DNA is 340 Å . It contains 20% Adenine . Calculate total no of hydrogen bonds. QUERY: It is the question and I am confused what approach to take! If I do it by converting it into nucleotide I am getting 260 hydrogen bonds and if by taking that 20 basepairs out of 100 are adenine thymine base pairs and that then the answer comes to be different! What approach should I take?

Q. What is degenerate codons?

1. One code which determine the same amino acid in all organisms
2. Any one codon specifies the position of one kind of amino acid only
3. A single amino acid may be specified by many codons
4. Codons do not code for any amino-acid

Q. What would be the Wobble pairing for GAG?

1. CUC
2. CUU
3. Both A and C
4. AUG

Q. Which of the following is a Wobble base pairs?

1. Hypoxanthine-uracil (I-U)
2. Guanine-uracil (G-U)
3. Hypoxanthine-adenine (I-A)
4. All of the above

Q. A double stranded DNA molecule of length 3.4 mm has 30000 cytosine, then calculate the total number of thymine nucleotides present in DNA?

1. 200
2. 4700
3. 47000
4. 470000

Q.

In a taxonomic key, couplet means

1. contrasting characters in a pair.

2. supplementary characters in a pair.

3. complementary characters in a pair.

4. none of these.

Q. Which among these is the wobble pair?

1. 3’ nucleotide of the tRNA and 5’ nucleotide of the mRNA
2. 5’ nucleotide of the tRNA and 3’ nucleotide of the mRNA
3. 5’ nucleotide of the tRNA and 5’ nucleotide of the mRNA
4. 3’ nucleotide of the tRNA and 3’ nucleotide of the mRNA

Q. A phenomenon, where the third base of rRNA at its 5' end can pair with a non-complementary base of mRNA is called

1. Universality
2. Colinearity
3. Degeneracy
4. Wobbling

Q. The codon for anticodon 3' UUUA-5' is

1. 5' AAAU-3'
2. 3 UAAD-5
3. 3' AAAU-5
4. 5' UAAA-3

Q. A strand of DNA has following base sequence 3' AAAAGTGACTAGTGA 5'. On transcription, it produces an mRNA which of the following anticodon of tRNA recognizes the third codon of this mRNA?

1. AAA
2. CUG
3. GAC
4. CTG

Q. What is degenerate codons?

1. One code which determine the same amino acid in all organisms
2. Any one codon specifies the position of one kind of amino acid only
3. A single amino acid may be specified by many codons
4. Codons do not code for any amino-acid

Q. If codon in mRNA is AAA. what will be the anticodon for it.

1. UUU
2. AAA
3. TTT
4. AUG

Q. In the double helix model of DNA, what would be the distance between two consecutive base pairs?

1. 3.4 nm
2. 20 nm
3. 2 nm
4. 0.34 nm

Q. A nonsense/termination codon is

1. GCG
2. UUU
3. UAG/UAA
4. CCC

Q. Chromosomal theory of inheritance was proposed by

1. Morgan and Boveri
2. Sutton and Boveri
3. Mendel and Morgan
4. Boveri and Mendel

Q. Regarding the assertion and reason, select the correct option.
Assertion $\left[A\right]$: There are only about 40 tRNA molecules for the 61 coding codons.
Reason $\left[R\right]$: The third base of the codon/anticodon have some unconventional base pairing.

1. Both A and R are true and R explains A
2. Both A and R are true, but R does not explain A
3. A is true and R is false
4. Both A and R are false

Q. Assertion :Wobble hypothesis explains the phenomena of multiple codons coding for the code for a single amino acid. Reason: One tRNA molecule can recognise and bind to more than one codon, due to the less-precise base pairs.

1. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion
2. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
3. Assertion is correct but Reason is incorrect
4. Both Assertion and Reason are incorrect

Q. In Wobble hypothesis, the pairing of the tRNA anticodon with the mRNA codon proceeds from

1. 3'-5 end
2. 5'-3' end
3. None of the above
4. Bidirectional

Q. Wobble hypothesis deals with

1. Phenomena of multiple codons coding for the code for a single amino acid
2. Phenomena of multiple codons coding for the code for a different amino acid
3. Phenomena of anticodon coding for the code for a different amino acid
4. Phenomena of anticodon coding for the code for more than one amino acid

Q. Explain 'Wobble hypothesis' with the help of a suitable diagram.

Q. Wobble hypothesis for genetic code was given by

1. Bernfield and Nirenberg
2. Crick
3. Creighton
4. Hedges

Q. Wobble hypothesis was proposed by

1. Holley
2. Nirenberg
3. Khorana
4. Crick

Q. Which among these is the wobble pair?

1. 3’ nucleotide of the tRNA and 5’ nucleotide of the mRNA
2. 5’ nucleotide of the tRNA and 3’ nucleotide of the mRNA
3. 5’ nucleotide of the tRNA and 5’ nucleotide of the mRNA
4. 3’ nucleotide of the tRNA and 3’ nucleotide of the mRNA

Q. Regarding the assertion and reason, select the correct option.
Assertion $\left[A\right]$: There are only about 40 tRNA molecules for the 61 coding codons.
Reason $\left[R\right]$: The third base of the codon/anticodon have some unconventional base pairing.

1. Both A and R are true and R explains A
2. Both A and R are true, but R does not explain A
3. A is true and R is false
4. Both A and R are false

Q. Why in double stranded DNA, number of purines equal the number of pyrimidines?

Q. Template theory suggests

1. Amino acids have to be activated
2. All of the above
3. Acylation
4. Combination of amino acid with tRNA first

Q. A phenomenon, where the third base of rRNA at its 5' end can pair with a non-complementary base of mRNA is called

1. Universality
2. Degeneracy
3. Colinearity
4. Wobbling

Q. Assertion :tRNA recognises its corresponding codon in mRNA. Reason: For each codon, there is an individual mRNA.

1. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion
2. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
3. Assertion is correct but Reason is incorrect
4. Both Assertion and Reason are incorrect

Q. Regarding the assertion and reason, select the correct option.
Assertion $\left[A\right]$: There are only about 40 tRNA molecules for the 61 coding codons.
Reason $\left[R\right]$: The third base of the codon/anticodon have some unconventional base pairing.

1. Both A and R are true and R explains A
2. Both A and R are true, but R does not explain A
3. A is true and R is false
4. Both A and R are false

Q. Choose the correct answers from the alternatives given :
The phenmomenon known as wobble refers to

1. the movement of multiple ribosomes along the same mRNA
2. the shifting of the reading frame in a deletion or insertion mutation
3. the ability of a tRNA to pair with different codons that may differ in the third base
4. the movement of a tRNA from the A to the P site