During conversion of pyruvic acid into acetyl CoA, pyruvic acid is
A
Reduced
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B
Oxidised
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C
Isomerised
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D
Condensed
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Solution
The correct option is B Oxidised The pyruvic acid generated in the glycolysis enters into the mitochondrial matrix, undergoes oxidative decarboxylation and forms active acetate in a coordinated series of reactions catalyzed by the multienzyme complex. The reaction requires the participation of an enzyme pyruvate dehydrogenase and several coenzymes including NAD+, coenzyme A, thiamine pyrophosphate and lipoic acid.