The correct option is A Base is deleted or added
The gene mutations that alter the base sequence of the whole genetic frame from the point of the mutation are called as frame shift mutations. Here, the reading frame of the base sequence is shifted forward (due to insertion of one or more nucleotide base) or in the backward direction (due to deletion of one or more nucleotide base); options B and C are incorrect as both deletion or addition can cause frame shift mutation. The tRNA has anticodon loop with a triplet at the tip which base pairs with the corresponding codon in mRNA, it is not the cause of mutation; option D is incorrect. The correct option is A.