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Question

Immediate hypersensitivity, which result in the release of histamine and other inflammatory substances is mediated by


A
IgA
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B
IgD
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C
IgE
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D
IgG
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Solution

The correct option is C IgE
Immunoglobulin E or IgE is a kind of antibody that has only been found in mammals. IgE plays an important role in type-I hypersensitivity or immediate hypersensitivity. IgE can specifically recognise an allergen, such as dust mite, grass, pollen etc. and has a unique long-lived interaction with its high-affinity receptor, so that basophils and mast cells are ready to release chemicals, like histamine, leukotrienes and certain interleukins.
Thus, the correct answer is option C.

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