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Question
In DNA replication, the leading strand is the one which replicates in
In DNA replication, the leading strand is the one which replicates in
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Solution
The correct option is A 5' → 3' direction continuously
DNA synthesis always occurs in the 5'-->3' because chain growth results from the formation of a phosphodiester bond between the 3' OH of a growing strand and α-phosphate of a dNTP. This makes options B and D wrong. The DNA strand in which DNA synthesis in 5'-->3' direction proceeds continuously in the same direction as replication fork movement is called leading strand. This makes option A correct. The lagging strand synthesis occurs in the 5'-->3' direction but proceeds in the opposite direction from the movement of the replication fork. This is done by synthesizing a new primer every few hundred bases on the second parental strand. Each of these primers is elongated in the 5'-->3' direction and form discontinuous segments called Okazaki fragments. Thus, option C is incorrect for leading strand.
DNA synthesis always occurs in the 5'-->3' because chain growth results from the formation of a phosphodiester bond between the 3' OH of a growing strand and α-phosphate of a dNTP. This makes options B and D wrong. The DNA strand in which DNA synthesis in 5'-->3' direction proceeds continuously in the same direction as replication fork movement is called leading strand. This makes option A correct. The lagging strand synthesis occurs in the 5'-->3' direction but proceeds in the opposite direction from the movement of the replication fork. This is done by synthesizing a new primer every few hundred bases on the second parental strand. Each of these primers is elongated in the 5'-->3' direction and form discontinuous segments called Okazaki fragments. Thus, option C is incorrect for leading strand.
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