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Question

Match column I (Types of T-cells) with column II (Function) and select the correct option.

Column I Column II
A. Helper T cells 1. Directly attack and kill a cell
B. Cytotoxic T cells 2. Prevent attacking own cell
C. Suppressor T cells 3. Prevent exaggerated immune response
D. T delayed hypersensitivity cells 4. Activation of B cells

A
A - 4, B - 1, C - 2 and D - 3
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B
A - 3, B - 1, C - 4 and D - 2
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C
A - 2, B - 3, C - 4 and D - 1
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D
A - 2, B - 4, C - 1 and D - 3
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Solution

The correct option is A A - 4, B - 1, C - 2 and D - 3
Lymphocytes are white blood cells that originate, mature and proliferate in specialised organs known as lymphoid organs which are made up of lymphoid tissues.

T-lymphocytes are produced in bone marrow but are matured in the thymus (a lobed primary lymphoid organ located near the heart and beneath the breastbone).

Maturation allows the T-lymphocytes to distinguish between self and non-self components of the body. The T-lymphocytes after maturation migrate to the secondary lymphoid organs like spleen, tonsils, lymph nodes, etc., for proliferation. There they come in contact with trapped antigens, bind with them via specific surface receptors and get sensitised to them.

Sensitisation causes the T-lymphocytes to proliferate by dividing and differentiating into four different types of cells based on the situation.

Functionally T-cells can be classified into regulator cells and effector cells. Helper T cells and Suppressor T cells are regulator cells.

Effector cells are of two types like the cytotoxic T cells and the delayed type hypersensitivity cells. All T-cells are able to produce memory T cells.
  • T helper cells - Helps in activation of B cells to produce antibodies.
  • T suppressor cells - Suppress the function of the cytotoxic and helper cells to prevent excessive immune response.
  • T cytotoxic cells - Directly attack and kill a cell or microorganism.
  • T delayed hypersensitivity cells - Helps in delaying the hypersensitivity reactions (exaggerated immune response to a less potent antigen).
Figure : Types of T-lymphocytes

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