One gene-one enzyme hypothesis was postulated by-

R. Franklin

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Hershey and Chase

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A.Garrod

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Beadle and Tatum

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Solution

The correct option is D Beadle and Tatum
The one gene-one enzyme hypothesis, proposed by George Wells Beadle in the US in 1941, is the theory that each gene directly produces a single enzyme, which consequently affects an individual step in a metabolic pathway.

So, the correct answer is 'Beadle and Tatum'.

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