The correct option is C Epinephrine- binds to intracellular receptor
Epinephrine is an amino-acid derivative hormone, which is water-soluble. Growth hormone is a protein hormone, which is also water-soluble. Since both epinephrine and growth hormone are water soluble, they cannot cross the cell membrane. Therefore, they produce second messengers. These second messengers include cyclic adenosine monophosphate (cyclic AMP), inositol-1,4,5-triphosphate IP3, and calcium ions.
Thyroxine is an iodothyronine, which is a lipid soluble hormone.