What is the reason for graft rejection?

T cell mediated immune rejection

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B cell mediated immune rejection

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Both A and B

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MHC incompatibility

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Solution

The correct options are
A
T cell mediated immune rejection

D
MHC incompatibility

During a kidney or a heart transplant, it is very important to find a suitable organ donor. MHC molecules help in self and non-self recognition because MHC molecules differ from one person to another. If the MHC of the donor and recipient do not match, the T cells recognise the new graft as non-self and launch an attack. This leads to the rejection of the graft by the patient's immune system.

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Similar questions

Transplantation of tissues/organs to save certain patients often fails due to rejection of such tissues/organs in the patient’s body. Which type of immune response is responsible for such rejection? [1]

(a) Auto-immune response

(b) Humoral immune response

(d) Cell-mediated immune response

Q. Consider the following statements regarding kidney transplant and select two correct ones out of these
a. Even if a kidney transplant is proper, the recipient may need to immune suppressants for a long time.
b. The cell-mediated immune response is responsible for the graft rejection
c.

β

-lymphocytes are responsible for rejection of the graft
d. Acceptance or rejection of a kidney transplant depends upon specific interferons.

Q. Consider the following four statement (i-iv) regarding kidney transplant and select the correct statements
(i) Even if a kidney transplant is proper the recipient may need to take immuno-suppressants for a long time.
(ii) The cell-mediated immune response is responsible for the graft rejection.
(iii) The B-lymphocytes are responsible for rejection of the graft.
(iv) The acceptance or rejection of a kidney transplant depends on specific interferons.

The correct statements are

Q. Which type of Immunity is responsible for graft Rejection?

Q. Which of the following immune responses is responsible for rejection of kidney graft?

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