Which antibiotic inhibits interaction between tRNA and mRNA during bacterial protein synthesis?

Neomycin

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Streptomycin

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Tetracycline

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Erythromycin

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Solution

The correct option is C Tetracycline
Tetracycline interferes with the attachment of tRNA carrying the amino acid to the mRNA-ribosome complex preventing the addition of amino acids to the growing polypeptide chain. Streptomycin interferes with the initial steps of protein synthesis by changing the shape of 30S proton of 70S prokaryotic ribosome. Erythromycin reacts with 50S portion of the 70S prokaryotic ribosome. Thus, the correct option is C.

Suggest Corrections

Similar questions

	List I		List II
A	Chloramphenicol	p	Inhibits binding of aminoacyl tRNA to ribosome
B	Erythromycin	q	Inhibits interaction between tRNA and mRNA
C	Neomycin	r	Inhibits initiation of translation
D	Streptomycin	s	Inhibits peptidyl transferase activity
E	Tetracycline	t	Inhibits translocation of mRNA along ribosomes

	Column I		Column II
(a)	Chloramphenicol	(p)	Inhibits binding of aatRNA to ribosome
(b)	Erthromycin	(q)	Inhibits interaction between tRNA and mRNA
(c)	Neomycin	(r)	Inhibits initiation of translation
(d)	Streptomycin	(s)	Inhibits peptidyl transferase activity
(e)	Tetracycline	(t)	Inhibits translocation of mRNA over ribosome

\begin{matrix} C o l u m n I & C o l u m n I I (a) & C h l o r a m p h e n i c o l & (p) & I n h i b i t s b i n d i n g o f a m i n o a c y l t R N A t o r i b o s o m e (b) & E r y t h r o m y c i n & (q) & I n h i b i t s i n t e r a c t i o n b e t w e e n t R N A a n d m R N A (c) & N e o m y c i n & (r) & I n h i b i t s i n i t i a t i o n o f t r a n s l a t i o n (d) & S t r e p t o m y c i n & (s) & I n h i b i t s p e p t i d y l t r a n s f e r a s e a c t i v i t y (e) & T e t r a c y c l i n e & (t) & I n h i b i t s t r a n s l o c a t i o n o f m R N A a l o n g r i b o s o m e s \end{matrix}

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