Which of the following is NOT true with regard to Chargaff’s rules?

A:T = 1:1

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G:C =1:1

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A+T : G+C = 1:1

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A+G : T+C = 1:1

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Solution

The correct option is C A+T : G+C = 1:1
According to Chargaff’s rules, the total amount of purines $(A + G)$ always equals the total amount of pyrimidines $(T + C)$ . Since adenine pairs with thymine, we could say that the amount of A equals the amount of T; likewise guanine always pairs with cytosine and hence, the amount of G equals the amount of C. However, A+T need not always be equal to G+C.

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