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Question

Which of the following means of post-transcriptional control in eukaryotes is not true?

A
The capping of the 5 end with a modified guanosine triphosphate
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B
The addition of a poly-A tail to the 3 end
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C
The attachment of signal sequences for direction to specific destinations
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D
The ligation of exons by DNA polymerase
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E
Both C and D
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Solution

The correct option is E Both C and D
Capping of eukaryotic mRNAs refers to the addition of 7-Methylguanosine to the 5’ end of almost all eukaryotic mRNAs in an unusual 5’,5’- triphosphate linkage. Tailing refers to cleavage of 3’ end and the addition of 80 to 250 A residues to create a poly(A) tail. Splicing is the removal of introns from the primary transcript and ligation of exons to form a continuous sequence specifying a functional polypeptide. The ligated exons are joined together by DNA ligase. The signal sequence is associated with protein targeting. Thus, the correct answer is option E.

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