Question

Which one of the following cannot be used for preparation of vaccination against plague?

• A. Heat killed suspension of virulent bacteria
• B. Formaline inactivated suspension of virulent bacteria
• C. A virulent live bacteria
• D. Synthetic capsular polysaccharide material

Answer 1

The correct option is D Synthetic capsular polysaccharide material

• Plague is an infectious disease caused by the bacterium Yersinia pestis.
• Killed bacteria have been used since 1890 but are less effective against pneumonic plague so that recently live vaccines of an attenuated type and recombination protein vaccines have been developed to prevent the disease.
• Synthetic capsular polysaccharide vaccines are used for the treatment of pneumonia and meningitis.
• Hence, Synthetic capsular polysaccharide material cannot be used for the preparation of vaccination against the plague.
• So, the correct answer is 'Synthetic capsular polysaccharide material'.