Semi Discontinuous Replication

Q.

Why is DNA replication bidirectional ?

Q.

Why okazaki fragments are formed?

Q.

What is the first step in DNA replication?

Q.

Can DNA polymerase initiate replication on its own?

Q.

What is a replication bubble?

Q.

What happens after DNA replication is completed?

Q.

What is the main goal of DNA replication?

Q.

Where does DNA replication occur?

Q.

Why is the double helix shape of DNA important?

Q.

The enzyme which helps to cut one strand of DNA duplex to release the tension of coiling of two strands is?

1. Topoisomerase

2. DNA ligase

3. Helicases or unwindases

4. DNA Polymerase

Q.

What are Okazaki fragments?

Q.

Which of the following regarding DNA replication, is/are correct?

1. On the template with polarity 5’ 3’, replication is discontinuous

2. Both the strands of the parental DNA double helix serve as templates

3. On the template with polarity 3’ 5’, replication is continuous

4. All the above

Q.

Regarding the assertion and reason, select the correct option.

Assertion $\left[A\right]$: DNA replication is semiconservative in nature.

Reason \left [ R \right ]: One of the DNA strands is synthesised continuously, while the other is synthesised discontinuously.

1. Both A and R are true and R explains A

2. A is true and R is false

3. Both A and B are true, but R does not explain A

4. Both A and R are false

Q.

Paragraph for below question

नीचे दिये गये प्रश्न के लिए अनुच्छेद

In φ × 174 bacteriophage virus, DNA is circular but in human genome, the genetic material is linear DNA. DNA is a long polymer of nucleotides. In 1953, the first double helical structure of DNA was proposed by Watson and Crick on the basis of X-ray diffraction data produced by Maurice Wilkins and Rosalind Franklin. It is composed of three components, i.e., a phosphate group, a deoxyribose sugar and a nitrogenous base.

Based on the above paragraph, answer the following questions.

φ × 174 जीवाणुभोजी वायरस में, डीएनए (DNA) वृत्ताकार होता है परंतु मानव जीनोम में, आनुवंशिक पदार्थ रेखीय डीएनए (DNA) होता है। डीएनए (DNA) न्यूक्लियोटाइड्स का एक लंबा बहुलक है। 1953 , में डीएनए (DNA) की पहली द्वि-कुंडली संरचना को वॉटसन तथा क्रिक ने मौरिस विल्किन्स व रोजलिंड फ्रैंकलिन द्वारा दिए गए एक्स-रे विवर्तन के आँकड़ों के आधार पर प्रस्तुत किया। यह तीन घटकों अर्थात् एक फॉस्फेट समूह, एक डिऑक्सीराइबोज शर्करा तथा एक नाइट्रोजनी क्षार का बना होता है।

उपरोक्त अनुच्छेद के आधार पर, निम्नलिखित प्रश्नों के उत्तर दीजिए।

Q. How many phosphodiester bonds are present in genetic material of φ × 174 bacteriophage virus?

प्रश्न - φ × 174 जीवाणुभोजी वायरस के आनुवंशिक पदार्थ में कितने फॉस्फोडाएस्टर बंध होते हैं?

1. 5384
2. 48502
3. 5386
4. 48501

Q. During replication of DNA, Okazaki fragments are formed in which direction?

1. $5^{\prime }\to 3^{\prime }$
2. $3^{\prime }\to 5^{\prime }$
3. $3^{\prime }\to 3^{\prime }$
4. $5^{\prime }\to 5^{\prime }$

Q.

DNA replication requires which of the following enzymes?

1. DNA polymerase only

2. DNA polymerase and ligase

3. Ligase only

4. RNA polymerase

Q. Which of the given histone proteins is not a part of the nucleosome core?

दिया गया कौनसा हिस्टोन प्रोटीन न्यूक्लियोसोम कोर का भाग नहीं होता है?

1. H₂A
2. H₁
3. H₃
4. H₄

Q. How many of the following statements are correct ?

A. DNA dependent DNA polymerase requires DNA primer for initiating replication but DNA dependent RNA polymerase does not require any primer for transcription.

B. DNA dependent DNA polymerase requires RNA primer for initiating replication but DNA dependent RNA polymerase does not require any primer for transcription.

C. During replication, unwinding of DNA double helix forms a fork-like structure called replication fork.

D. During transcription, unwinding of the DNA double helix by DNA dependent RNA polymerase forms a transcription bubble.

E. During transcription, unwinding of DNA double helix by DNA dependent RNA polymerase forms a transcription fork.

1. 4
2. 2
3. 5
4. 3

Q.

What is the role of Okazaki fragments in DNA chain growth?

1. Result in transcription
2. Polymerize in the 3' to 5' direction and forms replication fork
3. Prove semi-conservative nature of DNA replication
4. Polymerize in the 5' to 3' direction and explain 3' to 5' DNA replication

Q.

Semi-discontinuous mode of DNA replication was discovered by

Q. DNA synthesis during replication is ______i_____ and RNA synthesis during transcription is_____ii_______.

1. i- semi-discontinuous, ii- semi-discontinuous
2. i- semi-discontinuous, ii- continuous
3. i- continuous, ii- semi-discontinuous
4. i- continuous, ii- continuous

Q.

This section contains 1 Matrix Match type question, which has 2 Columns (Column I and Column II). Column I has four entries (A), (B), (C) and (D), Column II has four entries (P), (Q), (R) and (S). Match the entries in Column I with the entries in Column II. Each entry in Column I may match with one or more entries in Column II.
इस खण्ड में 1 मैट्रिक्स मिलान प्रकार का प्रश्न है, जिसमें 2 कॉलम (कॉलम I तथा कॉलम II) हैं। कॉलम I में चार प्रविष्टियाँ (A), (B), (C) तथा (D) हैं, कॉलम II में चार प्रविष्टियाँ (P), (Q), (R) तथा (S) हैं। कॉलम I में दी गयी प्रविष्टियों का मिलान कॉलम II में दी गयी प्रविष्टियों के साथ कीजिए। कॉलम I में दी गयी प्रत्येक प्रविष्टि का मिलान कॉलम II में दी गयी एक या अधिक प्रविष्टियों के साथ हो सकता है।

Match the Columns and choose the appropriate answer

कॉलमों का मिलान करें और सही उत्तर चुनें

	Column-I कॉलम-I		Column-II कॉलम-II
(A)	Helicase हेलीकेज	(P)	Requires RNA primer for initiation of replication प्रतिकृतीयन के आरंभन के लिए आरएनए (RNA) प्राइमर की आवश्यकता होती है
(B)	RNA polymerase आरएनए (RNA) पॉलिमरेज	(Q)	Unwinds DNA helix डीएनए (DNA) कुंडली को खोलता है
(C)	DNA polymerase डीएनए (DNA) पॉलिमरेज	(R)	Synthesises nucleotide chain न्यूक्लियोटाइड शृंखला का संश्लेषण करता है
(D)	Reverse transcriptase रिवर्स ट्रांसक्रिप्टेज	(S)	Follows principle of complementarity पूरकता के सिद्धांत का पालन करता है

1. A-Q, B-QRS, C-PRS, D-RS
2. A-P, B-PQ, C-PRS, D-RS
3. A-RS, B-QR, C-PRS, D-RS
4. A-PQRS, B-QS, C-PR, D-RS

Q.

Which of the following regarding DNA replication, is/are correct?

1. Both the strands of the parental DNA double helix serve as templates

2. On the template with polarity 3’$\to$5’, replication is continuous

3. On the template with polarity 5’$\to$3’, replication is discontinuous

4. All the above

Q. The presence of Okazaki fragments in the DNA replication process makes it clear that DNA replication is ___________.

1. Conservative
2. Semiconservative
3. Discontinuous
4. Semidiscontinuous

Q.

what do you meant by semi-conservative mode of replication of DNA?

Q. During DNA replication, the addition of nucleotides on the lagging strand occurs

1. Towards the replicating fork
2. Continuously
3. At a faster rate than leading strand
4. Discontinuously

Q. The Okazaki fragments in DNA chain growth

1. Result in transcription.
2. Polymerize in the 3' - 5' direction and forms replication fork.
3. Prove semi-conservative nature of DNA replication.
4. Polymerize in the 5' - 3' direction and explain 3' - 5' DNA replication

Q. The presence of Okazaki fragments in the DNA replication process makes it clear that DNA replication is ___________.

1. Conservative
2. Semiconservative
3. Discontinuous
4. Semidiscontinuous

Q.

Which of the following regarding DNA replication, is/are correct?

1. Both the strands of the parental DNA double helix serve as templates

2. On the template with polarity 3’ 5’, replication is continuous

3. On the template with polarity 5’ 3’, replication is discontinuous

4. All the above

Q. What is the error in above diagram?

1. Arrows are wrongly depicted.
2. Polarity is incorrect.
3. Both arrows and polarity are incorrect.
4. None of the above.