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One gene - one enzyme relationship was established for the first time in
One gene - one enzyme relationship was established for the first time in
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Solution
The correct option is A Neurospora crassa
George Beadle and Edward Tatum gave the molecular definition of a gene, while working on nutritional mutants in Neurospora. They exposed spores of the fungus Neurospora crassa to X-rays and other agents which damage DNA and cause alterations in DNA sequence (mutations). They observed that mutant fungal strains which lacked one or another specific enzyme, sometimes exhibit the failure of an entire metabolic pathway. It was concluded that a gene is a segment of genetic material that codes for one enzyme; the one gene–one enzyme hypothesis which was modified to one gene–one polypeptide, because many genes products are not enzymes and many gene codes for one polypeptide of a multi-subunit protein.
George Beadle and Edward Tatum gave the molecular definition of a gene, while working on nutritional mutants in Neurospora. They exposed spores of the fungus Neurospora crassa to X-rays and other agents which damage DNA and cause alterations in DNA sequence (mutations). They observed that mutant fungal strains which lacked one or another specific enzyme, sometimes exhibit the failure of an entire metabolic pathway. It was concluded that a gene is a segment of genetic material that codes for one enzyme; the one gene–one enzyme hypothesis which was modified to one gene–one polypeptide, because many genes products are not enzymes and many gene codes for one polypeptide of a multi-subunit protein.
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