Cancer

Q. Now a days it is possible to detect the mutated gene causing cancer by allowing radioactive probe to hybridise its complimentry DNA in a clone of cells, followed by its detection using autroradiography because:

1. mutated gene does not appear on photographic film as the probe has complimentarity with it.
2. mutated gene partially appears on a photographic with it.
3. mutated gene compeletely and clearly appears on a photographic film.
4. mutated gene does not appear on photographic film as the probe has no complimentarity with it.

Q. Carcinoma refer to:

1. 
   Malignant tumours of the connective tissue
2. 
   Malignant tumours of the skin or mucous membrane
3. 
   Malignant tumours of the colon
4. 
   Benign tumours of the connective tissue

Q. Transgenic models have been developed for many human diseases. These include
A. cancer
B. cystic fibrosis
C. rheumatoid arthritis
D. Alzheimer’s disease
Select the correct option

1. A and C
2. B and D
3. A, B, C and D
4. C and D

Q. How many of the given statements are correct regarding the applications of transgenic animals?
1. To study how the genes are regulated and how they affect the normal functioning of the body.
2. To study diseases like cystic fibrosis, cancer, Alzheimer's disease etc.
3. To produce biological products.
4. To test the safety of vaccines and chemicals.

1. Two
2. Three
3. Four
4. One

Q. Which of the following statements is not true for cancer cells in relation to mutations?

1. Mutations in proto – oncogenes accelerate the cell cycle
2. Mutations destroy telomerase inhibitor
3. Mutations inactivate the cell control
4. Mutations inhibit production of telomerase

Q. Regarding assertion and reason, choose the correct option
Assertion [A]: Interferon alpha helps in treatment of cancer indirectly
Reason [R]: Interferons alpha is a biological response modifier

1. A is true and R is false
2. Both A and R are true and R explains A
3. Both A and R are true R does not explain A
4. Both A and R are false

Q.

Oncology is the study of__________.

Q. The substance produced by a cell in viral infection that can protect other cells from further infection is:

1. interferon
2. colostrum
3. histamine
4. serotonin
   

Q. Drugs used to quickly reduce the symptoms of allergy
(i) Histaminic drugs
(ii) Adrenaline
(iii) Steroids
(iv) ɑ-interferons

1. ii and iii
2. i and ii
3. i, ii and iv
4. i, ii and iii

Q. Character of acquired immunity is

1. All of the above
2. Specificity of antigen
3. Retains memory
4. Difference between self and non-self

Q. Statement I: Proto oncogenes have been identified in normal cells.

Statement II: Proto oncogenes could lead to oncogenic transformation of the cells if activated.

1. Both the statements I and II are correct
2. Both the statements I and II are incorrect
3. Statement I is incorrect and statement II is correct
4. Statement I is correct and statement II is incorrect

Q.

Carcinoma refers to:

1. Malignant tumours of the skin or mucous membrane

2. Benign tumours of the connective tissue

3. Malignant tumours of the colon

4. Malignant tumours of the connective tissue

Q. Recognize the figure and find out the correct matching:

1. a-sexually, b-asexually
2. a-asexually, b-sexually
3. a-asexually, b-parthenogenetically
4. a-sexually, b-parthenogenetically

Q.

Sickle cell anemia is a case of

1. Transition mutation

2. Transversion mutation

3. Frameshift mutation

4. Silent mutation

Q. Transgenic animals are being produced for various purposes. Select the option which includes all the correct reasons with reference to above mentioned statement.

(a) Transgenic animals allow the study of how genes are regulated
(b) For investigation of new treatments for diseases
(c) For production of biological products
(d) For vaccine safety testing

1. (a) and (b) only
2. (c) and (d) only
3. (b) and (c) only
4. (a), (b), (c) and (d)

Q. What is the life span of an animal cell?

Q. ______have been identified in normal human cells which, when activated under certain conditions, could transform normal cells into cancerous cells.

1. Oncogenes
2. Proto oncogenes
3. V-onc genes
4. Both a and c

Q. Which of the following best defines an oncogene ?

1. An oncogene codes for a protein which prevents the cell from undergoing apoptosis
2. An oncogene codes for a cell cycle control protein
3. An oncogene codes for a mutated form of a protein which forms part of a signal transduction pathway
4. An oncogene is dominantly expressed mutation which gives a cell a growth or survival advantage

Q. Vitamin E is also called _______ vitamin and has ________ properties.

1. anti-pregancy; abortive
2. anti-sperm; sperm cell lysis
3. antisterility; antioxidative
4. fat-soluble; hydrophilic

Q.

Question 33
Name the pathological condition when uncontrolled cell division occurs.

Q. The drug cyclosporin used for organ transplant patients is obtained from:

1. Bacterium
2. Fungus
3. Virus
4. Plant

Q.

How does DNA get damaged?

Q. If a patient is advised Anti Retroviral Therapy, which infection is he suffereing from? Name the causative organism.

Q.

IUV is commonly used in clinical nephrology. All are true except

a) risky in pre existent renal disease

b) risky in myeloma

c) the risk of contrast nephropathy can be redused by avoiding dehydration and giving diuretics

d) risky in diabetes mellitus

Q. When a foreign DNA is introduced into an organism, how is it maintained in the host and how is it transferred to the progeny of the organism?

Q. A salt retaining hormone responsible for reabsorption of ${\mathrm{Na}}^{+}$ and water from renal tubules is:

1. ANF
2. Renin
3. ADH
4. Aldosterone

Q. Which one of the following is not a property of cancerous cells?

1. They compete with normal cells
2. They show contact inhibition
3. They divide uncontrollably
4. They do not remain confined to the area of origin

Q. Attempts are being made to produce pharmaceutical products from transgenic animals for which among the following diseases?
A. Phenylketonuria
B. Emphysema
C. Cystic fibrosis

1. A only
2. B only
3. A and C only
4. A, B and C

Q.

Where is Mycoplasma found?

Q.

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