Question

Is anisole undergoes Friedel crafts reaction?

Answer 1

1. In the presence of anhydrous aluminium chloride$\left({\mathrm{AlCl}}_3\right)$ as a catalyst, anisole reacts with acetyl chloride$\left({\mathrm{CH}}_3\mathrm{COCI}\right)$ to form $2-\mathrm{methoxy}\mathrm{acetophenone}$ and $4-\mathrm{methoxy}\mathrm{acetophenone}$.
2. The reaction is the acylation reaction by Friedel Craft (an electrophilic aromatic substitution reaction) and given in detail diagram below:

2. The detailed mechanism of the reaction is given below:

1. The Methoxy group is the $\mathrm{ortho}-\mathrm{para}$ group of directors.